The Destiny's Child singer's 67-year-old dad is set to reveal his battle against the disease on Good Morning America on Wednesday.
Mathew spoke to GMA's Michael Strahan, which they revealed in a teaser clip for the exclusive pre-recorded interview on Twitter on Tuesday.
Strahan is seen asking the music business executive: "How was it to tell your family about the diagnosis?"
The former manager of Destiny's Child - which launched his daughter Beyonce to super stardom - is seen wearing black-framed glasses and a charcoal trouser suit.
His white shirt is open collared as he sits opposite the television host for the revelation.
Mathew also shared to his own Twitter account that he would be making an announcement on the popular breakfast TV show.
He split from Beyonce's mum Tina in 2011 after 30 years of marriage, and shares daughters Beyonce and Solange with his ex-wife.
The music manager also shares daughter Koi and son Nixon with current wife Gena Avery.
Mathew is a longtime supporter of his daughters' careers, especially Bey's.
"I think that's the beauty of her creativity and I think that's what makes it so special, is that it relates to everyone," he told E! News after the release of Lemonade in 2016.
He added: "Every one of us have been disappointed before and have had to go through the grieving process of anger and, you know, disappointment and then acceptance and forgiveness.
"And I think that's why this again is touching so many people, because it's universal. Everybody can relate to it."
Mathew founded his music management company in 1992 and managed Destiny's Child who had their first hit in 1999, as well as producing or executive producing their music.
He was accused by members of the band of favouritism for his daughter Beyonce and Kelly Rowland.
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